This disorder is commonly known as depression and is in fact a serious biological disease believed to be associated with changes of chemicals in the brain such as serotonins and norepinephrine. Correct diagnosis by a health professional is essential and is based on the following.
First a patient must demonstrate at least two weeks of depressed mood or loss of interest accompanied by at least four additional symptoms of depression which include constant sadness, irritability, hopelessness, trouble sleeping, low energy or fatigue, feeling worthless or guilty for no reason, significant weight change, difficulty concentrating and loss of interest in favorite activities.
Patient diagnosis is based upon the patient's self-reported experience, behavior reported by relatives or friends and a mental status exam. Other disorders should be ruled out first before Major Depression Disorder is diagnosed and the tests for these are blood tests measuring thyroid function to rule out hypothyroidism, basic electrolytes and serum calcium to rule out metabolic disorders, full blood count to rule out a systemic infection or chronic disease and testosterone levels in men to rule out hypogonadism.
People usually present themselves to their family doctor with physical complaints rather than that of a mood disorder. These complaints can include stomachaches, headaches or even general fatigue. These physical complaints are real; they are not due to a physical illness, but rather to the Major Depression Disorder. While in childhood, both boys and girls are affected equally. Adults show that twice as many females are affected than males. A mental status exam is necessary along with the above mentioned tests to diagnosis Major Depression Disorder. Diagnosing Major Depression Disorder by the health professional is essential for the treatment and well-being of the patient.

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